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KMID : 0370220160600040207
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Yakhak Hoeji
2016 Volume.60 No. 4 p.207 ~ p.210
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Synthesis of a Bioactive Chromano-dihydrochalcone Derived from Metrodorea stipularis
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Han Young-Taek
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Abstract
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A concise synthesis of natural bioactive chromano-dihydrochalcone derived from Metrodorea stipularis has been
accomplished. Claisen-Schmidt aldol reaction of chromano-acetophenone with benzaldehyde afforded a key benzyl protected chalcone interemediate, subject to one-pot hydrogenation/hydrogenolysis using palladium hydroxide. This synthetic procedure would facilitate synthesis of the natural chromano-dihydrochalcones and their derivatives.
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KEYWORD
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Synthesis, dihydrochalcone, chromane, Claisen-Schmidt aldol condensation, one-pot hydrogenation/hydrogenolysis enolysis
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